
How are dietary supplements actually regulated?
Supplements reach shelves without FDA approval, but they are not unregulated — here is what the FDA and NIH say manufacturers actually have to do, before and after a product goes on sale.
Supplements grades products by the strength of evidence behind them: creatine, caffeine, beta-alanine, nitrates, protein powders and a long tail of unproven blends. Entries list effective dose, timing, expected effect size and third-party testing status. For athletes and coaches deciding what deserves shelf space and what does not.
Creatine, beta-alanine, caffeine, nitrates and the rest ranked by trial quality and effect size, with dosing, timing and third-party testing status stated.

Supplements reach shelves without FDA approval, but they are not unregulated — here is what the FDA and NIH say manufacturers actually have to do, before and after a product goes on sale.

Creatine is one of the few supplements with strong evidence behind it — for short-duration strength and power, in trained and untrained adults alike — and weaker evidence for the newer claims on its label frontier.

Synthetic stimulants and plant-derived beta-2 agonists keep appearing in supplements labeled as natural — and both sport and regulators treat them as prohibited or unlawful.

From a 2004 IOC-lab study finding undeclared prohormones in about 15 percent of samples to modern stimulant adulteration, contamination is documented, category-specific and manageable.

Small trials report collagen peptides raising markers of collagen synthesis and easing activity-related joint pain — the evidence base stays thin and short-term.

Recent pooled analyses put beta-alanine's benefit near 2.85 percent — concentrated in efforts lasting about one to ten minutes.

Raw monohydrate prices have eased from their 2024 peak while a boom in creatine gummies pulls the market toward new formats, per industry data.

US rules require a proprietary blend to list its ingredients by weight order and its total weight — but not a single individual amount.

Warning letters are public, dated enforcement documents — and reading them directly is more reliable than any summary of enforcement trends.

Independent tests of protein powders have detected cadmium, lead, arsenic and mercury at varying levels — mostly trace, occasionally elevated, and never zero.